Arginase-1, HepPar-1, and Glypican-3 Are the Most Effective Panel of Markers in Distinguishing Hepatocellular Carcinoma From Metastatic Tumor on Fine-Needle Aspiration Specimens
نویسندگان
چکیده
منابع مشابه
diagnostic value of arginase-1 and glypican-3 in differential diagnosis of hepatocellular carcinoma, cholangiocarcinoma and metastatic carcinoma of liver
conclusions the findings of this study reveal that both arg-1 and gpc-3 are helpful ihc markers to separate hcc from cc and ma. furthermore, arg-1 shows 100% sensitivity and 82.6% specificity for the diagnosis of hcc whereas gpc-3 demonstrated 97.7% sensitivity and 91.3% specificity for the diagnosis of this tumor. results arginase-1 and gpc-3 demonstrated diffuse staining, as reactivity in > 9...
متن کاملDiagnostic Value of Arginase-1 and Glypican-3 in Differential Diagnosis of Hepatocellular Carcinoma, Cholangiocarcinoma and Metastatic Carcinoma of Liver
BACKGROUND Hepatocellular carcinoma is the most common primary liver cancer. Pathologic distinction between Hepatocellular Carcinoma (HCC) and adenocarcinoma (Cholangiocarcinoma (CC) and Metastatic Adenocarcinoma (MA)) can be challenging and sometimes requires immunohistochemical panels. Recently, Arginase-1 (ARG-1) and Glypican-3 (GPC-3) have been introduced for differentiation of these tumors...
متن کاملThe diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to HepPar-1
BACKGROUND The ability to distinguish hepatocellular carcinoma (HCC) from metastatic carcinoma (MC) involving the liver and cholangiocarcinoma (CC) by immunohistochemistry has been limited by the lack of a reliable positive marker for hepatocellular differentiation. Arginase-1 is a marker for HCC recently described in some literature. AIM To examine the immunohistochemical staining of arginas...
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Merkel cell carcinoma (MCC) is uncommon cutaneous malignant neuroendocrine tumour of the elderly people with rapidly growing skin nodules found frequently on sun-exposed areas of the body. MCC is often an aggressive tumour with high tendency for local recurrence, lymph node involvement and distant metastases. This paper reports a case of metastatic MCC diagnosed by fine needle aspiration cytolo...
متن کامل3 Fine Needle Aspiration
Research Article 1 2 3 4 5 Amrita Raj ,Amit Pandey , Ankita Raj , Gauri Mishra , Abhinav Misra , Saket Nigam 1. Reader, Department of Oral and Maxillofacial Pathology, Rama Dental College, Hospital & Research Centre, Kanpur. 2. Reader, Department of Periodontology and Oral Implantology, Rama Dental College, Hospital & Research Centre, Kanpur. 3. Reader, Department of Oral and Maxillofacial Surg...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2012
ISSN: 1943-7722,0002-9173
DOI: 10.1309/ajcpk1zc9wnhccmu